導師姓名：李文娟
科研方向：腫瘤代謝與化學預防；
個人簡介：李文娟，女，博士，畢業于首都醫科大學,2009年至2014年在美國肯塔基大學和路易斯安那州立大學進行博士後訓練。bevictor伟德官网引進人才，現任職于bevictor伟德官网，受聘副教授，2016年獲得藥理學碩士導師資格。長期以來一直緻力于腫瘤發生發展分子機制、腫瘤代謝與化學預防的研究。已在《Cancer Prevention Research》等本領域權威期刊以第一作者發表SCI論文16篇，共發表論文30餘篇，主持國家基金委青年基金項目一項，省自然科學基金面上項目兩項，省人社廳基金一項，及校内基金兩項。指導本科生申請并完成大學生創新創業省級項目四項，并承擔生物與分子生物學等7門本科專業課程的教學任務。

二、研究方向
腫瘤發生發展的分子機制。
腫瘤代謝與化學預防的相關研究。
天然提取物在腫瘤發生發展中的作用機制研究

三、科研、教改項目

科研項目
2019年河北省自然科學基金面上項目，項目編号：H2019201084， 2019-2021，在研，主持人。醉茄素A通過IDH1抑制有氧糖酵解并影響肝髒腫瘤發生發展的機制研究

國家青年基金，項目批準号：81502477，2016-2018，已結題，主持人。醉茄素A穩定IDH1及線粒體功能抑制皮膚腫瘤早期發生發展的機制研究

河北省留學人員科技活動項目擇優資助項目，項目編号：C2015003021，2016-2018，已結題，主持人。

2015年河北省自然科學基金資助面上項目，項目編号：H2015201119， 2015-2017，已結題，主持人。

學科建設項目，項目編号：2015A1001，2015-2017，已結題，主持人。

bevictor伟德官网引進人才項目，項目編号：2015-307，2015至今，在研，主持人。

教改項目
2020年bevictor伟德官网題（卷）庫項目，2020年，申請人。

bevictor伟德官网精品實驗重點項目，2018-2019，實時定量PCR檢測小鼠肝髒管家基因β-actin，參與。

四、代表性論文
Kaiyue Xu, Chunjing Zhang, Youbo Li, Xin Xi, Lishuang Zheng, Ming Meng, Tongtong Liu, Yunfeng Zhao, Wenjuan Li. Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation. Translational Cancer Research，2019: 8,2449-2460.

Xuemeng Wang, Limin Chang, Xiaojie Lang, Heng An, Yong Wang, Wenjuan Li, Jianglei Qin. Cross-linking induced thermo-responsive self-healable hydrogels with temperature regulated light emission property. Journal of Polymer Research. May 2019: 26,115.

Liye Cao*, Wen-Juan Li*, Ji-Hong Yang, Yu Wang, Zhi-Juan Hua, Dan Liu, Ya-Qing Chen, Hao-Miao Zhang, Rui Zhang, Ji-Sen Zhao, Shu-Jie Cheng, Quan Zhang. Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression. Oncology Letters. 2019: 17, 3163-3172.

Xuemeng Wang, Kaiyue Xu, Haicui Yao, Limin Chang, Yong Wang, Wenjuan Li, Youliang Zhao, Jianglei Qin. Temperature-Regulated Aggregation-Induced Emissive Self-Healable Hydrogel for Controlled Drug Delivery. Polymer Chemistry. 2018: 9:5002-5013.

Heng An, Kaiyue Xu, Limin Chang, Yong Wang, Jianglei Qin#, Wenjuan Li#. Thermo-responsive self-healable hydrogels with extremely mild base degradability and bio-compatibility. Polymer. 2018: 147:38-47.

許凱悅，張春晶，李文娟。IDH1在腫瘤發生發展中的作用及其調控機制的研究進展。中國腫瘤生物治療雜志。2018: 25（6）：573-579.

王林林，嶽培林，張鑫，李文娟. 三磷酸腺苷結合盒轉運子E1功能及其在疾病中作用的研究進展. 山東醫藥. 2017；57（12）：101-103.

Wenjuan li, Chunjing Zhang, H Du, V Huang, B Sun, JP Harris, Q Richardson, X Shen, Rong Jin, Guohong Li, CG Kevil, Xin Gu, Runhua Shi, Yunfeng Zhao. Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model. Mol Carcinog. 2016 Nov;55(11):1739-1746. doi: 10.1002/mc.22423. Epub 2015 Oct 16.

Wenjuan Li, Chunjing Zhang, Amy Ren, Tinna Li, Rong Jin, Guohong Li, Xin Gu, Runhua Shi, Yunfeng Zhao. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. PLOS ONE, 10(5), e0126459,May 11 2015.

Wenjuan Li, Chunjing Zhang, Jackson K, Shen X, Jin R, Li G, Kevil CG, Gu X, Shi R, Yunfeng Zhao. UCP2 knockout suppresses mouse skin carcinogenesis. Cancer Prev Res, 8(6), 487-491,JUN 2015.

Wenjuan Li, Chunjing Zhang, Runhua Shi, Xin Gu, Yunfeng Zhao. Mitochondrial uncoupling protein 2 promotes skin carcinogenesis. CANCER RESEARCH, 439(74),OCT 1 2014. (Meeting Abstract)

Wenjuan Li, Joan Liu and Yunfeng Zhao. PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells. Molecular Carcinogenesis, 53(5),403-412,MAY 2014.

Wenjuan Li, Joan Liu, Kasey Jackson, Runhua Shi, Yunfeng Zhao. Sensitizing the Therapeutic Efficacy of Taxol with Shikonin in Human Breast Cancer Cells. PLOS ONE, 9(4), e94079,APR 7 2014.

Wenjuan Li, Krystle Nichols, Cherie-Ann Nathan and Yunfeng Zhao. Mitochondrial uncoupling protein 2 is up-regulated in human head and neck, skin, pancreatic, and prostate tumors. Cancer Biomarkers 13(5), 377-383, 24 Dec 2013.

Wenjuan Li and Yunfeng Zhao. Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. Cancer Sci, 104(2), 143-148,FEB 2013.

Wenjuan Li and Yunfeng Zhao. “Warburg Effect” and Mitochondrial Metabolism in Skin Cancer. J Carcinogene Mutagene, S4, 002,2012.

Delira Robbins, Wenjuan Li, Katie Humphrey and Yunfeng Zhao. Redox factor-1 mediates inflammatory response during tumor promotion in skin epidermal JB6 cells. Scientific Research, 1(3), 19-24,2012.

Xiaoling Guo*, Wenjuan Li*, Qing Wang, and Hsin-Sheng Yang. AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation. Genes & Cancer, 2011; 2: 818-828. (*These authors contributed equally to this work.)

Haijun Zhang, Wenjuan Li, Michael J. Franklin, and Arkadiusz Z. Dudek. Polymorphisms in DNA Repair Gene XRCC1 and Skin Cancer Risk: A Meta-analysis. ANTICANCER RESEARCH, 2011; 31: 3945-3952.

Hai-Jun Zhang, Wen-Juan Li, Yan-Yan Gu, Shu-Yan Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Jia. p14ARF interacts with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription. J Cell Biochem, 2010; 109: 693-701.

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